تاثیرات سمیت عصبی بیسفنول A بر روی یادگیری و حافظه فضایی در رت های نر

Background and purpose: Bisphenol A is a synthetic xenoestrogen that is used in large amount to produce polymers (polycarbonates, epoxy resins). It easily cross the blood-brain barrier and is reported to influence the central nervous system especially neurogenesis and synaptic transmission. In this research the effects of chronic administration of bisphenol A on spatial learning and memory in adult male rats was studied. Materials and methods: Forty male Wistar rats were randomly divided into four groups (n= 10); a control and three BPA (10 and 50 and 100 &micro;g/kg) groups. Bisphenol A was administered intraperitoneally for 15 days. The morris water maze was used to study the spatial learning and memory for 5 consecutive days. Data analysis was performed using one-way ANOVA. Results: Compared with the control group, treatment with BPA in 10 and 50 &micro;g/kg doses reduced spatial memory (P<0.05). Reduction of spatial memory in the group treated with 100 &mu;g/kg BPA was very severe compared with the control group (P<0.01). Conclusion: Results showed that bisphenol A increased the distance and latency time in finding the hidden platform. It seems that bisphenol A has negative effects on spatial memory by affecting synaptic transmission in central nervous system.